Greg Kelley began studying the trumpet at age 10. He attended the Peabody Conservatory of Music in Baltimore, where in addition to studying the Conservatory curriculum, he also immersed himself in a deep study of avant-garde and experimental music, eventually coming to the conclusion that his musical focus fell outside of the academic sphere. After his studies, Kelley moved back to his native Massachusetts, quickly insinuated himself into the local avant-garde circles and soon commenced a period of intense travel and collaboration, bringing him throughout North America, Europe, Japan, Argentina and Mexico. In 2014, he relocated to Seattle.
He has appeared on over 90 recordings and plays in a number of long running groups including Nmperign (with Bhob Rainey), the BSC, and Heathen Shame (with Wayne Rogers & Kate Village of Major Stars). Other collaborators have included Jandek, Keiji Haino, Donald Miller (Borbetomagus), Anthony Braxton, Kevin Drumm, Christian Wolff, Pauline Oliveros, Joe McPhee, and Lionel Marchetti. In addition to playing the trumpet, Kelley has also recorded music using electronics and musique concrete elements, sometimes utilizing trumpet based sound sources, other times not.